Project coordinated by Prof. Rikard Landberg of Chalmers University of Technology.
DESCRIPTION
The human gut microbiota has been linked with incidence and progression of non-communicable diseases and their risk factors. Moreover, diet has been identified as an important modulator of microbiota composition and function, but responses vary between individuals. The underlying mechanisms of diet – microbiota interactions remain to be elucidated to provide a foundation for tailored dietary strategies for personalized precision nutrition. The aim of the DiGuMet project is to investigate how gut microbiota interact with diet and to identify the role of these interactions on cardiometabolic risk factors. In this project the underlying mechanisms will be further dissected through extensive metabotyping using metagenomics and metabolomics combined with lifestyle data in a free-living prospective cohort subset. The hypothesis is that gut microbiota – diet interactions are a major determinant of the metabotypes and that distinct metabotypes could be reflected by predictive biomarkers. These biomarkers could then be used to tailor personalised dietary interventions to improve the molecular phenotypes among subjects at elevated risk of cardiovascular diseases. The hypothesis will be tested by conducting a dietary intervention rich in fermentable vs non-fermentable cereal fibres among subjects with signs of metabolic syndrome with distinct differences in their pattern of microbiota and microbiota-derived metabolites.
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